2kbt: Difference between revisions

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==Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method==
==Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method==
<StructureSection load='2kbt' size='340' side='right'caption='[[2kbt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2kbt' size='340' side='right'caption='[[2kbt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G'] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbt OCA], [https://pdbe.org/2kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbt RCSB], [https://www.ebi.ac.uk/pdbsum/2kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbt ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbt OCA], [https://pdbe.org/2kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbt RCSB], [https://www.ebi.ac.uk/pdbsum/2kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/VAV_MOUSE VAV_MOUSE]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.  
[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.[https://www.uniprot.org/uniprot/VAV_MOUSE VAV_MOUSE] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strsg]]
[[Category: Mus musculus]]
[[Category: Inagaki, F]]
[[Category: Streptococcus sp. 'group G']]
[[Category: Kobashigawa, Y]]
[[Category: Synthetic construct]]
[[Category: Kumeta, H]]
[[Category: Inagaki F]]
[[Category: Ogura, K]]
[[Category: Kobashigawa Y]]
[[Category: Gb1]]
[[Category: Kumeta H]]
[[Category: Inset]]
[[Category: Ogura K]]
[[Category: Intein]]
[[Category: Protein ligation]]
[[Category: Signaling protein]]
[[Category: Solubility enhancement]]
[[Category: Sortase]]

Revision as of 08:43, 14 June 2023

Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method

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