2ksb: Difference between revisions

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==Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R==
==Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R==
<StructureSection load='2ksb' size='340' side='right'caption='[[2ksb]], [[NMR_Ensembles_of_Models | 5 NMR models]]' scene=''>
<StructureSection load='2ksb' size='340' side='right'caption='[[2ksb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ksb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ksb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSB FirstGlance]. <br>
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</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN]] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. [[https://www.uniprot.org/uniprot/TKN1_HUMAN TKN1_HUMAN]] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.  
[https://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gayen, A]]
[[Category: Gayen A]]
[[Category: Mukhopadhyay, C]]
[[Category: Mukhopadhyay C]]
[[Category: Autodock]]
[[Category: Dmpc/chaps/gm1 bicelle]]
[[Category: Neuropeptide receptor-neuropeptide complex]]
[[Category: Nk1r]]
[[Category: Substance p]]
Retrieved from "https://proteopedia.org/2ksb"