1fva: Difference between revisions

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[[Image:1fva.~~gif~~|left|200px]]

[[Image:1fva.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE~~'''~~

===CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE===

~~==Overview==~~

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~~Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free methionine and methionine within proteins. As such~~, ~~it helps protect~~ the ~~host organism against stochastic damage that can contribute~~ to ~~cell death~~. ~~The structure of bovine MsrA has been determined in two different modifications~~, ~~both of which provide different insights into the biology of~~ the ~~protein~~. ~~There are three cysteine residues located in the vicinity of the active site. Conformational changes in a glycine~~-~~rich C~~-terminal tail appear to allow all three thiols to come together and to participate in catalysis. The structures support a unique, thiol-disulfide exchange mechanism that relies upon an essential cysteine as a nucleophile and additional conserved residues that interact with the oxygen atom of the sulfoxide moiety.

The line below this paragraph, {{ABSTRACT_PUBMED_11063566}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11063566 is the PubMed ID number.

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==About this Structure==

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[[Category: Weissbach, H.]]

[[Category: Oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:48:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:59:51 2008''

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-[[Image:1fva.gif|left|200px]]
+{{Seed}}
+[[Image:1fva.png|left|200px]]
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 {{STRUCTURE_1fva|  PDB=1fva  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE'''
+===CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE===
-==Overview==
+<!--
-Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free methionine and methionine within proteins. As such, it helps protect the host organism against stochastic damage that can contribute to cell death. The structure of bovine MsrA has been determined in two different modifications, both of which provide different insights into the biology of the protein. There are three cysteine residues located in the vicinity of the active site. Conformational changes in a glycine-rich C-terminal tail appear to allow all three thiols to come together and to participate in catalysis. The structures support a unique, thiol-disulfide exchange mechanism that relies upon an essential cysteine as a nucleophile and additional conserved residues that interact with the oxygen atom of the sulfoxide moiety.
+The line below this paragraph, {{ABSTRACT_PUBMED_11063566}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11063566 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11063566}}
 ==About this Structure==
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 [[Category: Weissbach, H.]]
 [[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:48:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:59:51 2008''