6kyr: Difference between revisions

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<StructureSection load='6kyr' size='340' side='right'caption='[[6kyr]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='6kyr' size='340' side='right'caption='[[6kyr]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6kyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KYR FirstGlance]. <br>
<table><tr><td colspan='2'>[[6kyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KYR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.206&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCLK1, DCAMKL1, DCDC3A, KIAA0369 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyr OCA], [https://pdbe.org/6kyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyr RCSB], [https://www.ebi.ac.uk/pdbsum/6kyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyr OCA], [https://pdbe.org/6kyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyr RCSB], [https://www.ebi.ac.uk/pdbsum/6kyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN]] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.  
[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Chen Q]]
[[Category: Chen, Q]]
[[Category: Yu Y]]
[[Category: Yu, Y]]
[[Category: Autoinhibition]]
[[Category: Kinase]]
[[Category: Signaling protein]]

Latest revision as of 10:47, 22 November 2023

Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain

6kyr, resolution 2.21Å

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