1fw1: Difference between revisions

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[[Image:1fw1.jpg|left|200px]]
{{Seed}}
[[Image:1fw1.png|left|200px]]


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{{STRUCTURE_1fw1|  PDB=1fw1  |  SCENE=  }}  
{{STRUCTURE_1fw1|  PDB=1fw1  |  SCENE=  }}  


'''GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE'''
===GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE===




==Overview==
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Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate. Deficiencies in enzymes along the degradation pathway lead to serious diseases including phenylketonuria, alkaptonuria, and the fatal disease, hereditary tyrosinemia type I. The structure of MAAI might prove useful in the design of inhibitors that could be used in the clinical management of the latter disease. Here we report the crystal structure of human MAAI at 1.9 A resolution in complex with glutathione and a sulfate ion which mimics substrate binding. The enzyme has previously been shown to belong to the zeta class of the glutathione S-transferase (GST) superfamily based on limited sequence similarity. The structure of MAAI shows that it does adopt the GST canonical fold but with a number of functionally important differences. The structure provides insights into the molecular bases of the remarkable array of different reactions the enzyme is capable of performing including isomerization, oxygenation, dehalogenation, peroxidation, and transferase activity.
The line below this paragraph, {{ABSTRACT_PUBMED_11327815}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11327815}}


==About this Structure==
==About this Structure==
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[[Category: Polekhina, G.]]
[[Category: Polekhina, G.]]
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:49:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:01:43 2008''

Revision as of 01:01, 1 July 2008

File:1fw1.png

Template:STRUCTURE 1fw1

GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE

Template:ABSTRACT PUBMED 11327815

About this Structure

1FW1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity., Polekhina G, Board PG, Blackburn AC, Parker MW, Biochemistry. 2001 Feb 13;40(6):1567-76. PMID:11327815

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