7sz2: Difference between revisions

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'''Unreleased structure'''


The entry 7sz2 is ON HOLD  until Paper Publication
==Mouse PARP13/ZAP ZnF5-WWE1-WWE2 bound to ATP==
 
<StructureSection load='7sz2' size='340' side='right'caption='[[7sz2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Ayanath Kuttiyatveetil, J.R., Pascal, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7sz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZ2 FirstGlance]. <br>
Description: Mouse PARP13/ZAP ZnF5-WWE1-WWE2 bound to ATP
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sz2 OCA], [https://pdbe.org/7sz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7sz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sz2 ProSAT]</span></td></tr>
[[Category: Pascal, J]]
</table>
[[Category: Ayanath Kuttiyatveetil, J.R]]
== Function ==
[https://www.uniprot.org/uniprot/ZCCHV_MOUSE ZCCHV_MOUSE] Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).<ref>PMID:21102435</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ayanath Kuttiyatveetil JR]]
[[Category: Pascal JM]]
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