7e5m: Difference between revisions
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==crystal structure of trans assembled human TROP-2== | ==crystal structure of trans assembled human TROP-2== | ||
<StructureSection load='7e5m' size='340' side='right'caption='[[7e5m]]' scene=''> | <StructureSection load='7e5m' size='340' side='right'caption='[[7e5m]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E5M FirstGlance]. <br> | <table><tr><td colspan='2'>[[7e5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E5M FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e5m OCA], [https://pdbe.org/7e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e5m RCSB], [https://www.ebi.ac.uk/pdbsum/7e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e5m ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e5m OCA], [https://pdbe.org/7e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e5m RCSB], [https://www.ebi.ac.uk/pdbsum/7e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e5m ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/TACD2_HUMAN TACD2_HUMAN] Honey-droplet corneal dystrophy;Gelatinous drop-like corneal dystrophy. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TACD2_HUMAN TACD2_HUMAN] May function as a growth factor receptor. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy, and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for the treatment of triple-negative breast cancer. Here, we report the crystal structures of TROP-2-ECD, which can be either cis- or trans-dimers depending on which distinct but overlapping interfaces is used to engage with monomers. The cis- or trans-tetrameric forms of TROP-2 can also be assembled with a non-overlapping interface with either cis- or trans-dimerization, suggesting that cis- and trans-dimers cluster on the cell surface. The binding site of sacituzumab on TROP-2 is mapped to be located on a stretched polypeptide in CPD (Q237-Q252), which is not involved in either cis- or trans-interactions. The present findings will improve understanding of the molecular assembly of TROP-2 on tumor cells and shed light on future design of biologics for tumor therapy. | |||
Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.,Sun M, Zhang H, Jiang M, Chai Y, Qi J, Gao GF, Tan S iScience. 2021 Sep 30;24(10):103190. doi: 10.1016/j.isci.2021.103190. eCollection, 2021 Oct 22. PMID:34693228<ref>PMID:34693228</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7e5m" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chai Y]] | [[Category: Chai Y]] | ||
Revision as of 16:46, 29 November 2023
crystal structure of trans assembled human TROP-2
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