Sandbox Reserved 1688: Difference between revisions

Line 19:

Catalytic Site –

The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions. The <~~active site~~ ='89/891378/Residues_stable_rna/1'>~~TextToBeDisplayed~~</scene> is "encircled" due to interactions between the thumb and fingers domain. In many polymerases, this structure undergoes a tightening conformation change when the substrate is bound. The HCV RdRp undergoes very minimal conformation change between bound and unbound active sites. The RdRp performs efficiently in native conformation. Internal cavities adjacent to the thumb domain are found between structural motifs C and E. This <scene name='89/891378/C_and_e_gap/2'>cavity</scene> is heavily preserved throughout all NS5B models.

The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions. The <scene name='89/891378/Residues_stable_rna/1'>active site</scene> is "encircled" due to interactions between the thumb and fingers domain. In many polymerases, this structure undergoes a tightening conformation change when the substrate is bound. The HCV RdRp undergoes very minimal conformation change between bound and unbound active sites. The RdRp performs efficiently in native conformation. Internal cavities adjacent to the thumb domain are found between structural motifs C and E. This <scene name='89/891378/C_and_e_gap/2'>cavity</scene> is heavily preserved throughout all NS5B models.

References -

Sandbox Reserved 1688: Difference between revisions

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@@ Line 19: / Line 19: @@
 Catalytic Site –
-The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions. The <active site ='89/891378/Residues_stable_rna/1'>TextToBeDisplayed</scene> is "encircled" due to interactions between the thumb and fingers domain. In many polymerases, this structure undergoes a tightening conformation change when the substrate is bound. The HCV RdRp undergoes very minimal conformation change between bound and unbound active sites. The RdRp performs efficiently in native conformation. Internal cavities adjacent to the thumb domain are found between structural motifs C and E. This <scene name='89/891378/C_and_e_gap/2'>cavity</scene> is heavily preserved throughout all NS5B models.
+The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions. The <scene name='89/891378/Residues_stable_rna/1'>active site</scene> is "encircled" due to interactions between the thumb and fingers domain. In many polymerases, this structure undergoes a tightening conformation change when the substrate is bound. The HCV RdRp undergoes very minimal conformation change between bound and unbound active sites. The RdRp performs efficiently in native conformation. Internal cavities adjacent to the thumb domain are found between structural motifs C and E. This <scene name='89/891378/C_and_e_gap/2'>cavity</scene> is heavily preserved throughout all NS5B models.
 References -