1fzv: Difference between revisions

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[[Image:1fzv.gif|left|200px]]
{{Seed}}
[[Image:1fzv.png|left|200px]]


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{{STRUCTURE_1fzv|  PDB=1fzv  |  SCENE=  }}  
{{STRUCTURE_1fzv|  PDB=1fzv  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION'''
===THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION===




==Overview==
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The angiogenic molecule placenta growth factor (PlGF) is a member of the cysteine-knot family of growth factors. In this study, a mature isoform of the human PlGF protein, PlGF-1, was crystallized as a homodimer in the crystallographic asymmetric unit, and its crystal structure was elucidated at 2.0 A resolution. The overall structure of PlGF-1 is similar to that of vascular endothelial growth factor (VEGF) with which it shares 42% amino acid sequence identity. Based on structural and biochemical data, we have mapped several important residues on the PlGF-1 molecule that are involved in recognition of the fms-like tyrosine kinase receptor (Flt-1, also known as VEGFR-1). We propose a model for the association of PlGF-1 and Flt-1 domain 2 with precise shape complementarity, consider the relevance of this assembly for PlGF-1 signal transduction, and provide a structural basis for altered specificity of this molecule.
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{{ABSTRACT_PUBMED_11069911}}


==About this Structure==
==About this Structure==
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[[Category: Cysteine-knot family]]
[[Category: Cysteine-knot family]]
[[Category: Growth factor]]
[[Category: Growth factor]]
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