Conservation, Evolutionary: Difference between revisions
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Unlike ConSurf, INTREPID does not identify the [[#Locating Variable Patches|most variable residues]] in addition to the [[#Locating Conserved Patches|most conserved]]. | Unlike ConSurf, INTREPID does not identify the [[#Locating Variable Patches|most variable residues]] in addition to the [[#Locating Conserved Patches|most conserved]]. | ||
===xProtCAS=== | |||
[http://slim.icr.ac.uk/projects/xprotcas xProtCAS] is a tool to identify conserved surfaces on AlphaFold2 structural models. The tool defines autonomous structural modules from the structural models and converts these modules to a graph encoding residue topology, accessibility, and conservation. xProtCAS is available as open-source Python software and as an interactive web server. | |||
"The xProtCAS web server represents a fast, simple, and intuitive tool to analyze protein surface conservation. The two comparable available web-based tools for conserved accessible surface discovery, PatchFinder, and FuncPatch web servers, were no longer functional at the time of publication. There are overlaps with the functionality of the ConSurf server. However, the definition of the most conserved accessible surface and integration with AlphaFold2 models of the xProtCAS server adds key functionality not available with the ConSurf server." (Quoted from the [https://www.mdpi.com/2218-273X/13/6/906 xProtCAS associated publication]().) | |||
===siteFiNDER|3D=== | ===siteFiNDER|3D=== | ||
