Sandbox Reserved 1091: Difference between revisions
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The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation. | The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation. | ||
In the '''kallikrein/kinin system''', the ASP induce the production of kinin from kininogen (low MW or high MW). The kinin also release caused edema at the infection site and shock in the circulation. | In the '''kallikrein/kinin system''', the ASP induce the production of kinin from kininogen (low MW or high MW). The kinin also release caused edema at the infection site and shock in the circulation. <ref>Mechanisms of Inflammation and Tissue Repair. Gary S. Firestein et al. Goldman’s Cecil Medicine (Twenty Fourth Edition) (2012)</ref> | ||
Experiments have been done in order to try to reduce the virulence activity of ASP. It has been demonstrated that the [http://fr.wikipedia.org/wiki/Alpha-2_macroglobuline α2-macroglobulin], a plasma protein, can limit ASP activity. This protein can bind to ASP which is thus inactivated. <ref>Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin. Murakami Y et al. Biol Chem. 393(10):1193-200 (2012)</ref> | Experiments have been done in order to try to reduce the virulence activity of ASP. It has been demonstrated that the [http://fr.wikipedia.org/wiki/Alpha-2_macroglobuline α2-macroglobulin], a plasma protein, can limit ASP activity. This protein can bind to ASP which is thus inactivated. <ref>Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin. Murakami Y et al. Biol Chem. 393(10):1193-200 (2012)</ref> | ||
