1g05: Difference between revisions

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[[Image:1g05.gif|left|200px]]
{{Seed}}
[[Image:1g05.png|left|200px]]


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{{STRUCTURE_1g05|  PDB=1g05  |  SCENE=  }}  
{{STRUCTURE_1g05|  PDB=1g05  |  SCENE=  }}  


'''HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS'''
===HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS===




==Overview==
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Potent and selective inhibition of matrix metalloproteinases was demonstrated for a series of sulfonamide-based hydroxamic acids. The design of the heterocyclic sulfonamides incorporates a six- or seven-member central ring with a P2' substituent that can be modified. Binding interactions of this substituent at the S2' site are believed to contribute to high inhibitory potency against stromelysin, collagenase-3 and gelatinases A and B, and to provide selectivity against collagenase-1 and matrilysin. An X-ray structure of a stromelysin inhibitor complex was obtained to provide insights into the SAR and selectivity trends observed for the series.
The line below this paragraph, {{ABSTRACT_PUBMED_11327577}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11327577}}


==About this Structure==
==About this Structure==
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[[Category: Mixed alpha beta structure]]
[[Category: Mixed alpha beta structure]]
[[Category: Zinc protease]]
[[Category: Zinc protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:57:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:12:04 2008''
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