7vf2: Difference between revisions
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==Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI)== | |||
<StructureSection load='7vf2' size='340' side='right'caption='[[7vf2]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7vf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF2 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf2 OCA], [https://pdbe.org/7vf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf2 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf2 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/VIR_HUMAN VIR_HUMAN]] Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).<ref>PMID:24981863</ref> <ref>PMID:29507755</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Deng T]] | |||
[[Category: Gao M]] | |||
[[Category: Li S]] | |||
[[Category: Liu J]] | |||
[[Category: Ma J]] | |||
[[Category: Peng C]] | |||
[[Category: Su S]] | |||
[[Category: Wu B]] | |||
[[Category: Yin Y]] | |||
[[Category: Zhang K]] | |||
Revision as of 06:56, 14 September 2022
Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI)
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