2bpd: Difference between revisions
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<StructureSection load='2bpd' size='340' side='right'caption='[[2bpd]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2bpd' size='340' side='right'caption='[[2bpd]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPD FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpd OCA], [https://pdbe.org/2bpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpd RCSB], [https://www.ebi.ac.uk/pdbsum/2bpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpd ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpd OCA], [https://pdbe.org/2bpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpd RCSB], [https://www.ebi.ac.uk/pdbsum/2bpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpd ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CLC7A_MOUSE CLC7A_MOUSE] Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.<ref>PMID:10779524</ref> <ref>PMID:11544516</ref> <ref>PMID:12719479</ref> <ref>PMID:15213161</ref> <ref>PMID:15729357</ref> <ref>PMID:15731053</ref> <ref>PMID:15845454</ref> <ref>PMID:16825490</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Brown | [[Category: Brown GD]] | ||
[[Category: Brown | [[Category: Brown J]] | ||
[[Category: Gilbert RJC]] | |||
[[Category: Gilbert | [[Category: Gordon S]] | ||
[[Category: Gordon | [[Category: Jones EY]] | ||
[[Category: Jones | [[Category: Marshall ASJ]] | ||
[[Category: Marshall | [[Category: O'Callaghan CA]] | ||
[[Category: | [[Category: Siebold C]] | ||
[[Category: C | |||
