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==Solution structure of the second SH3 domain of human adaptor protein NCK2==
==Solution structure of the second SH3 domain of human adaptor protein NCK2==
<StructureSection load='2frw' size='340' side='right'caption='[[2frw]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2frw' size='340' side='right'caption='[[2frw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2frw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2frw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fry|2fry]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frw OCA], [https://pdbe.org/2frw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frw RCSB], [https://www.ebi.ac.uk/pdbsum/2frw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frw OCA], [https://pdbe.org/2frw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frw RCSB], [https://www.ebi.ac.uk/pdbsum/2frw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>
[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liu, J]]
[[Category: Liu J]]
[[Category: Protein binding]]
[[Category: Sh3]]
Retrieved from "https://proteopedia.org/2frw"