7w6s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7w6s is ~~ON HOLD until Paper Publication~~

==CryoEM structure of human KChIP2-Kv4.3 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Guo JT]]

[[Category: Ma DM]]

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-'''Unreleased structure'''
-The entry 7w6s is ON HOLD  until Paper Publication
+==CryoEM structure of human KChIP2-Kv4.3 complex==
+<StructureSection load='7w6s' size='340' side='right'caption='[[7w6s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7w6s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6S FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6s OCA], [https://pdbe.org/7w6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6s RCSB], [https://www.ebi.ac.uk/pdbsum/7w6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6s ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KCIP2_HUMAN KCIP2_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).[UniProtKB:Q9JJ69]<ref>PMID:10676964</ref> <ref>PMID:11287421</ref> <ref>PMID:11684073</ref> <ref>PMID:12297301</ref> <ref>PMID:12829703</ref> <ref>PMID:14623880</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Guo JT]]
+[[Category: Ma DM]]