3b7l: Difference between revisions
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<StructureSection load='3b7l' size='340' side='right'caption='[[3b7l]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='3b7l' size='340' side='right'caption='[[3b7l]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3b7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3b7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7L FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0N:(1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>M0N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7l OCA], [https://pdbe.org/3b7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7l RCSB], [https://www.ebi.ac.uk/pdbsum/3b7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7l OCA], [https://pdbe.org/3b7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7l RCSB], [https://www.ebi.ac.uk/pdbsum/3b7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Dunford JE]] | |||
[[Category: Dunford | [[Category: Ebetino FH]] | ||
[[Category: Ebetino | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Guo K]] | ||
[[Category: Guo | [[Category: Kavanagh KL]] | ||
[[Category: Kavanagh | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Pilka ES]] | ||
[[Category: Pilka | [[Category: Russell RGG]] | ||
[[Category: Russell | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 12:03, 30 August 2023
Human farnesyl diphosphate synthase complexed with MG and minodronate
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