Sandbox Reserved 1660: Difference between revisions

Line 20:

'''CD1d protein''' is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system], involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated. Thus, the production of cytotoxic molecules such as ~~Th1, Th2,~~ [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma ~~INF~~-gamma] is triggered by this activation<ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref><ref name="affinity">Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https://doi.org/10.1038/nri3328.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].

'''CD1d protein''' is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system], involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated. Thus, the production of cytotoxic molecules such as [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma IFN-gamma] is triggered by this activation, leading to either a Th2 or Th1 immune response respectively <ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref><ref name="affinity">Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https://doi.org/10.1038/nri3328.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].

</p>

<br>

Sandbox Reserved 1660: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 20: / Line 20: @@
 <p align="justify">
-'''CD1d protein''' is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system], involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated. Thus, the production of cytotoxic molecules such as Th1, Th2, [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma INF-gamma] is triggered by this activation<ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref><ref name="affinity">Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https://doi.org/10.1038/nri3328.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].
+'''CD1d protein''' is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system], involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated. Thus, the production of cytotoxic molecules such as [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma IFN-gamma] is triggered by this activation, leading to either a Th2 or Th1 immune response respectively <ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref><ref name="affinity">Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https://doi.org/10.1038/nri3328.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].
 </p>
 <br>