Sandbox Reserved 1650: Difference between revisions
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== Composition and 3D structure <ref>DOI 32025030</ref> == | == Composition and 3D structure <ref>DOI 32025030</ref> == | ||
=== Global structure === | === Global structure === | ||
'''Human thyroglobulin''' is a dimeric glycoprotein (see a <scene name='86/868183/Monomer_tg/1'>monomer</scene>)consisting of '''2749 amino acid residues''' with a molecular weight of '''660 kDa'''. The average size of the dimer is '''120x235 Å'''. | '''Human thyroglobulin''' is a dimeric glycoprotein (see a <scene name='86/868183/Monomer_tg/1'>monomer</scene>)consisting of 2 times '''2749 amino acid residues''' with a molecular weight of '''660 kDa'''. The average size of the dimer is '''120x235 Å'''. | ||
Each of its monomers comprises '''5 distinct regions''' on which approximately 66 <scene name='86/868183/Tyr/1'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | Each of its monomers comprises '''5 distinct regions''' on which approximately 66 <scene name='86/868183/Tyr/1'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | ||
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There are 4 hormonogenic sites for <scene name='86/868183/Tg/3'>TG</scene> : | There are 4 hormonogenic sites for <scene name='86/868183/Tg/3'>TG</scene> : | ||
- an <scene name='86/868183/Site_a/2'>A site</scene>, comprising two fixed donor tyrosines Y234 and Y149 and one flexible acceptor tyrosine: Y24 [[https://www.youtube.com/watch?v=98MKFRc6S_w&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=4>Site A]] | - an <scene name='86/868183/Site_a/2'>A site</scene>, comprising two fixed donor tyrosines Y234 and Y149 and one flexible acceptor tyrosine: Y24 [[https://www.youtube.com/watch?v=98MKFRc6S_w&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=4>Site A]]. | ||
- a <scene name='86/868183/Site_b/ | - a <scene name='86/868183/Site_b/4'>B site</scene>, including one Y2573 donor and one Y2540 acceptor [[https://www.youtube.com/watch?v=aNd32NLk9Fk&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=3>Site B]]. | ||
- a C site, comprising both donor and acceptor tyrosine Y2766 | - a '''C site''', comprising both donor and acceptor tyrosine Y2766 (not resolved in the map). | ||
- a <scene name='86/868183/ | - a <scene name='86/868183/Site_d/1'>D site</scene>, comprising a Y108 donor and a Y1310 acceptor [[https://www.youtube.com/watch?v=JYUPk59lVVw&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=2>Site D]]. | ||
An acidic Asp (aspartic acid) or Glu (glutamic acid) residue always precedes the acceptor and a lysine is always close to the donor. | An acidic Asp (aspartic acid) or Glu (glutamic acid) residue always precedes the acceptor and a lysine is always close to the donor. | ||
