1g3j: Difference between revisions

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[[Image:1g3j.gif|left|200px]]
{{Seed}}
[[Image:1g3j.png|left|200px]]


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{{STRUCTURE_1g3j|  PDB=1g3j  |  SCENE=  }}  
{{STRUCTURE_1g3j|  PDB=1g3j  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''
===CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX===




==Overview==
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The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.
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{{ABSTRACT_PUBMED_11136974}}


==About this Structure==
==About this Structure==
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[[Category: Beta-catenin,tcf-3]]
[[Category: Beta-catenin,tcf-3]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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