7w7e: Difference between revisions
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==Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist== | |||
<StructureSection load='7w7e' size='340' side='right'caption='[[7w7e]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7w7e]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W7E FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W58:5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine'>W58</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w7e OCA], [https://pdbe.org/7w7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w7e RCSB], [https://www.ebi.ac.uk/pdbsum/7w7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w7e ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Du | [[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: Shoichet | == Function == | ||
[[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Du Y]] | |||
[[Category: Fink EA]] | |||
[[Category: Shoichet BK]] | |||
[[Category: Xu J]] | |||
Revision as of 06:18, 28 September 2022
Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist
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