UvrABC

spinqualitylabelsall models UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) 3pih Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function UvrABC endonuclease is an E. coli enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one. UvrA is the protein which locates the DNA damage. UvrB is involved in distinguishing damaged from undamaged DNA. The C-terminal region of UvrC is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair. UvrD is DNA helicase II. See Helicase. For details on the UvrA-UvrB complex see UvrA-UvrB interaction domains. Structural highlights UvrA contains several domains: UvrB-binding, DNA-binding and two ATP-binding domains.

3D structures of UvrABC

Updated on 21-June-2022

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• UvrA
  • Helicase – TmUvrA + DNA – Thermotoga maritima
    
  • UvrA-UvrB interaction domains - TmUvrA (mutant) + ADP
    
  • 3zqj – UvrA – Mycobacterium tuberculosis
    
  • 4dfc – EcUvrA + Transcription-repair-coupling factor – Escherichia coli
    
  • 2r6f – BstUvrA – Bacillus stearothermophilus
    
  • 3ux8 – GeUvrA - Geobacillus
    
  • 2vf7, 2vf8 – DrUvrA2 - Deinococcus radiodurans
    
• UvrB
  • 1d2m, 1c4o – TtUvrB – Thermus thermophilus
    
  • 1d9x – BcUvrB – Bacillus caldotenax
    
  • 1t5l – BcUvrB (mutant)
    
  • 1qoj – EcUvrB C terminal
    
  • 1e52 – EcUvrB C terminal - NMR
    
  • 1d9z – BcUvrB + ATP
    
  • 2fdc, 6o8f, 6o8g, 6o8h – BcUvrB + DNA
    
  • 6o8e – BcUvrB + DNA + ADP
    
  • 2d7d, 2nmv, 3v4r – BsUvrB + DNA – Bacillus subtilis
    
• UvrC
  • 1kft, 1qoj – EcUvrC C terminal
    
  • 1e52 – EcUvrC C terminal - NMR
    
  • 2nrr, 2nrt, 2nrv, 2nrw, 2nrx, 2nrz – TmUvrC C terminal
    
  • 1ycz, 1yd0, 1yd1 – TmUvrC N terminal
    
  • 1yd2, 1yd3, 1yd4, 1yd5 – TmUvrC N terminal (mutant)
    
  • 1yd6 – BcUvrC N terminal
    
  • 3c65 – BstUvrC
    
• UvrD or DNA helicase II see Helicase
• UvrA-UvrB
  • 3fpn – BstUvrA + UvrB
    
  • 3uwx – GeUvrA + UvrB
    
• UvrB-UvrD
  • 7egt – TtUvrB N-terminal + UvrD C-terminal
    

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Michal Harel, Alexander Berchansky