Sandbox Reserved 1653: Difference between revisions

From Proteopedia
Jump to navigationJump to search
No edit summary
No edit summary
 
Line 98: Line 98:
== Relevance ==
== Relevance ==


Even if a lot is already known about Piezo1's structure, the precise mechanism of the pore is still unknown. Moreover, Piezo1 is present in a large number of tissues, but the differences in its roles are unclear. Further research is required to allow a better understanding of diseases linked to Piezo1 (like DHS), and thus a better treatment of those diseases.  
A majority of Piezo1’s structure has been resolved by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-em] but still information is lacking on the N-term domain and some subregions. There is no full structure available yet which can be troublesome to understand the mechanism of the protein. Moreover, Piezo1 is present in a large number of tissues, but the differences in its roles are unclear. Further research is required to allow a better understanding of diseases linked to Piezo1 (like DHS), and thus a better treatment of those diseases.  


[http://www.rcsb.org/structure/5Z10 PBD]
[http://www.rcsb.org/structure/5Z10 PBD]