Sandbox Reserved 1650: Difference between revisions
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'''Introduction''' | '''Introduction''' | ||
[https://en.wikipedia.org/wiki/Thyroglobulin Human thyroglobulin (TG)] is a precursor of two [https://en.wikipedia.org/wiki/Thyroid_hormones thyroid hormones] (TH): tetraiodothyronine or [[thyroxine]] (T4) and [[triiodothyronine (T3)]], | [https://en.wikipedia.org/wiki/Thyroglobulin Human thyroglobulin (TG)] is a precursor of two [https://en.wikipedia.org/wiki/Thyroid_hormones thyroid hormones] (TH): tetraiodothyronine or [[thyroxine]] (T4) and [[triiodothyronine (T3)]], essential for '''growth''', '''development''' and the '''control of metabolism'''. Its structure is essential for the diagnosis, treatment and monitoring of thyroid-related diseases. | ||
== Composition and 3D structure <ref>DOI 32025030</ref> == | == Composition and 3D structure <ref>DOI 32025030</ref> == | ||
=== Global structure === | === Global structure === | ||
'''Human thyroglobulin''' is a dimeric glycoprotein (see a <scene name='86/868183/Monomer_tg/1'>monomer</scene>)consisting of 2 times '''2749 amino acid residues''' with a molecular weight of '''660 kDa'''. The average size of the dimer is '''120x235 Å'''. | '''Human thyroglobulin''' is a dimeric glycoprotein (see a <scene name='86/868183/Monomer_tg/1'>monomer</scene>) consisting of 2 times '''2749 amino acid residues''' with a molecular weight of '''660 kDa'''. The average size of the dimer is '''120x235 Å'''. | ||
Each of its monomers comprises '''5 distinct regions''' on which approximately 66 <scene name='86/868183/Tyr/1'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | Each of its monomers comprises '''5 distinct regions''' on which approximately 66 <scene name='86/868183/Tyr/1'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | ||
