Sandbox Reserved 1656: Difference between revisions

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==== Function ====

Deubiquitinases are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://en.wikipedia.org/wiki/Ubiquitin ubiquitin] of proteins. ~~These~~ enzymes ~~are thus~~ implicated in the regulation of '''protein degradation'''. Indeed, ~~when~~ a protein ~~is going~~ to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination(fr)] [https://en.wikipedia.org/wiki/Ubiquitin#Ubiquitylation (en)]. Following this step, mono or poly-ubiquitin is ~~removed~~ from the protein ~~which has been degraded, by deubiquitinase~~. ~~<ref>PMID:9409543</ref>~~

Deubiquitinases are key enzymes belonging to the vast group of '''proteases'''.They take part in the removal of ubiquitin molecules on proteins which have been ubiquitinated, allowing the degradation of [https://en.wikipedia.org/wiki/Ubiquitin ubiquitin]-tagged proteins. As a result, these enzymes play an important role being implicated in the regulation of '''protein degradation'''. Indeed, the pathway for a protein to be degraded involves, an enzymatic cascade that will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination(fr)] [https://en.wikipedia.org/wiki/Ubiquitin#Ubiquitylation (en)]. Following this step, mono or poly-ubiquitin is by deubiquitinases from the protein.

==== Families ====

Sandbox Reserved 1656: Difference between revisions

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@@ Line 8: / Line 8: @@
 ==== Function ====
-Deubiquitinases are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://en.wikipedia.org/wiki/Ubiquitin ubiquitin] of proteins. These enzymes are thus implicated in the regulation of '''protein degradation'''. Indeed, when a protein is going to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination(fr)] [https://en.wikipedia.org/wiki/Ubiquitin#Ubiquitylation (en)]. Following this step, mono or poly-ubiquitin is removed from the protein which has been degraded, by deubiquitinase. <ref>PMID:9409543</ref>
+Deubiquitinases are key enzymes belonging to the vast group of '''proteases'''.They take part in the removal of ubiquitin molecules on proteins which have been ubiquitinated, allowing the degradation of [https://en.wikipedia.org/wiki/Ubiquitin ubiquitin]-tagged proteins. As a result, these enzymes play an important role being implicated in the regulation of '''protein degradation'''. Indeed, the pathway for a protein to be degraded involves, an enzymatic cascade that will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination(fr)] [https://en.wikipedia.org/wiki/Ubiquitin#Ubiquitylation (en)]. Following this step, mono or poly-ubiquitin is by deubiquitinases from the protein.
 ==== Families ====