Sandbox Reserved 1660: Difference between revisions

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[[Image:C12DS.jpg | thumb ||left|190px|'''Ligand C12-di-sulfatide''']]

NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>.

The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>.

</p>

The <scene name='86/868193/Conformational_variations/1'>conformational variations</scene> of CD1d are induced by the binding of its ligand, for instance the C12-di-sulfatide.

Sandbox Reserved 1660: Difference between revisions

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@@ Line 47: / Line 47: @@
 [[Image:C12DS.jpg | thumb ||left|190px|'''Ligand C12-di-sulfatide''']]
 <p align="justify">
-NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>.
+The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>.
 </p>
 The <scene name='86/868193/Conformational_variations/1'>conformational variations</scene> of CD1d are induced by the binding of its ligand, for instance the C12-di-sulfatide.