1g4u: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1g4u.gif|left|200px]]
{{Seed}}
[[Image:1g4u.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g4u|  PDB=1g4u  |  SCENE=  }}  
{{STRUCTURE_1g4u|  PDB=1g4u  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1'''
===CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1===




==Overview==
<!--
Salmonella spp. utilize a specialized protein secretion system to deliver a battery of effector proteins into host cells. Several of these effectors stimulate Cdc42- and Rac1-dependent cytoskeletal changes that promote bacterial internalization. These potentially cytotoxic alterations are rapidly reversed by the effector SptP, a tyrosine phosphatase and GTPase activating protein (GAP) that targets Cdc42 and Rac1. The 2.3 A resolution crystal structure of an SptP-Rac1 transition state complex reveals an unusual GAP architecture that mimics host functional homologs. The phosphatase domain possesses a conserved active site but distinct surface properties. Binding to Rac1 induces a dramatic stabilization in SptP of a four-helix bundle that makes extensive contacts with the Switch I and Switch II regions of the GTPase.
The line below this paragraph, {{ABSTRACT_PUBMED_11163217}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11163217 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11163217}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Tyrosine phosphatase]]
[[Category: Tyrosine phosphatase]]
[[Category: Virulence factor]]
[[Category: Virulence factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:08:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:25:02 2008''

Revision as of 01:25, 1 July 2008

File:1g4u.png

Template:STRUCTURE 1g4u

CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1

Template:ABSTRACT PUBMED 11163217

About this Structure

1G4U is a Protein complex structure of sequences from Homo sapiens and Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1., Stebbins CE, Galan JE, Mol Cell. 2000 Dec;6(6):1449-60. PMID:11163217

Page seeded by OCA on Tue Jul 1 04:25:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1g4u&oldid=600516"