1g5m: Difference between revisions

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[[Image:1g5m.gif|left|200px]]
{{Seed}}
[[Image:1g5m.png|left|200px]]


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{{STRUCTURE_1g5m|  PDB=1g5m  |  SCENE=  }}  
{{STRUCTURE_1g5m|  PDB=1g5m  |  SCENE=  }}  


'''HUMAN BCL-2, ISOFORM 1'''
===HUMAN BCL-2, ISOFORM 1===




==Overview==
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The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-x(L) chimeras in which part of the putative unstructured loop of Bcl-2 was replaced with a shortened loop from Bcl-x(L). These chimeric proteins have a low pI compared with the wild-type protein and are soluble. The structures of the two Bcl-2 isoforms consist of 6 alpha-helices with a hydrophobic groove on the surface similar to that observed for the homologous protein, Bcl-x(L). Comparison of the Bcl-2 structures to that of Bcl-x(L) shows that although the overall fold is the same, there are differences in the structural topology and electrostatic potential of the binding groove. Although the structures of the two isoforms of Bcl-2 are virtually identical, differences were observed in the ability of the proteins to bind to a 25-residue peptide from the proapoptotic Bad protein and a 16-residue peptide from the proapoptotic Bak protein. These results suggest that there are subtle differences in the hydrophobic binding groove in Bcl-2 that may translate into differences in antiapoptotic activity for the two isoforms.
The line below this paragraph, {{ABSTRACT_PUBMED_11248023}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11248023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11248023}}


==About this Structure==
==About this Structure==
1G5M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5M OCA].  
1G5M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5M OCA].  


==Reference==
==Reference==
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[[Category: Yoon, H S.]]
[[Category: Yoon, H S.]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:09:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:28:35 2008''

Revision as of 01:28, 1 July 2008

File:1g5m.png


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1g5m, 1 NMR models (default scene)
Related: 1bxl, 1g5j, 1g5o
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN BCL-2, ISOFORM 1

Template:ABSTRACT PUBMED 11248023

About this Structure

1G5M is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the antiapoptotic protein bcl-2., Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3012-7. Epub 2001 Feb 27. PMID:11248023

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