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==Structure of P. aeruginosa PA17 CapW==
==Structure of P. aeruginosa PA17 CapW==
<StructureSection load='7tb5' size='340' side='right'caption='[[7tb5]]' scene=''>
<StructureSection load='7tb5' size='340' side='right'caption='[[7tb5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TB5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7tb5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TB5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tb5 OCA], [https://pdbe.org/7tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tb5 ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tb5 OCA], [https://pdbe.org/7tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tb5 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacteria use diverse immune systems to defend themselves from ubiquitous viruses termed bacteriophages (phages). Many anti-phage systems function by abortive infection to kill a phage-infected cell, raising the question of how they are regulated to avoid cell killing outside the context of infection. Here, we identify a transcription factor associated with the widespread CBASS bacterial immune system, that we term CapW. CapW forms a homodimer and binds a palindromic DNA sequence in the CBASS promoter region. Two crystal structures of CapW suggest that the protein switches from an unliganded, DNA binding-competent state to a ligand-bound state unable to bind DNA. We show that CapW strongly represses CBASS gene expression in uninfected cells, and that phage infection causes increased CBASS expression in a CapW-dependent manner. Unexpectedly, this CapW-dependent increase in CBASS expression is not required for robust anti-phage activity, suggesting that CapW may mediate CBASS activation and cell death in response to a signal other than phage infection. Our results parallel concurrent reports on the structure and activity of BrxR, a transcription factor associated with the BREX anti-phage system, suggesting that CapW and BrxR are members of a family of universal defense signaling proteins.
Control of bacterial immune signaling by a WYL domain transcription factor.,Blankenchip CL, Nguyen JV, Lau RK, Ye Q, Gu Y, Corbett KD Nucleic Acids Res. 2022 May 20;50(9):5239-5250. doi: 10.1093/nar/gkac343. PMID:35536256<ref>PMID:35536256</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7tb5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blankenchip CL]]
[[Category: Blankenchip, C L]]
[[Category: Corbett KD]]
[[Category: Corbett, K D]]
[[Category: Lau RK]]
[[Category: Lau, R K]]
[[Category: Nguyen JV]]
[[Category: Nguyen, J V]]
[[Category: Ye Q]]
[[Category: Ye, Q]]
[[Category: Dna binding protein]]
[[Category: Helix-turn-helix]]
[[Category: Transcription factor]]
[[Category: Winged helix]]
[[Category: Wyl]]
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