1g5z: Difference between revisions

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[[Image:1g5z.~~jpg~~|left|200px]]

[[Image:1g5z.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40~~'''~~

===CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40===

~~==Overview==~~

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The ~~outer surface protein C (OspC) is one of the major host-induced antigens of Borrelia burgdorferi~~, the ~~causative agent of Lyme disease. We have solved~~ the ~~crystal structure of recombinant OspC to a resolution of 2~~.~~5 A~~. ~~OspC, a largely alpha-helical protein~~, is ~~a dimer with a characteristic central four-helical bundle formed by association of~~ the ~~two longest helices from each subunit~~. ~~OspC is very different from OspA and similar to the extracellular domain of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei. Most of the surface~~-~~exposed residues of OspC are highly variable among different OspC isolates. The membrane proximal halves of the two long alpha~~-helices are the only conserved regions that are solvent accessible. As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines.

The line below this paragraph, {{ABSTRACT_PUBMED_11139584}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11139584 is the PubMed ID number.

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==About this Structure==

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[[Category: Alpha helix protein]]

[[Category: Surface protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:10:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:30:17 2008''

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-[[Image:1g5z.jpg|left|200px]]
+{{Seed}}
+[[Image:1g5z.png|left|200px]]
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 {{STRUCTURE_1g5z|  PDB=1g5z  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40'''
+===CRYSTAL STRUCTURE OF LYME DISEASE ANTIGEN OUTER SURFACE PROTEIN C (OSPC) FROM BORRELIA BURGDORFERI STRAIN N40===
-==Overview==
+<!--
-The outer surface protein C (OspC) is one of the major host-induced antigens of Borrelia burgdorferi, the causative agent of Lyme disease. We have solved the crystal structure of recombinant OspC to a resolution of 2.5 A. OspC, a largely alpha-helical protein, is a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit. OspC is very different from OspA and similar to the extracellular domain of the bacterial aspartate receptor and the variant surface glycoprotein from Trypanosoma brucei. Most of the surface-exposed residues of OspC are highly variable among different OspC isolates. The membrane proximal halves of the two long alpha-helices are the only conserved regions that are solvent accessible. As vaccination with recombinant OspC has been shown to elicit a protective immune response in mice, these regions are candidates for peptide-based vaccines.
+The line below this paragraph, {{ABSTRACT_PUBMED_11139584}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11139584 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11139584}}
 ==About this Structure==
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 [[Category: Alpha helix protein]]
 [[Category: Surface protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:10:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:30:17 2008''