Fel d 1: Difference between revisions

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=='''Introduction'''==

The major allergen in cats, [[Fel d 1]], belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>.

The major allergen in cats, '''Fel d 1''', belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>.

It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking <ref name="[1]"/><ref name="[3]">WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref>.

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 =='''Introduction'''==
 <StructureSection load='1puo' size='340' side='right' align='right' caption='Cat major allergen complex with MPD (PDB code [[1puo]])' scene=''/>
-The major allergen in cats, [[Fel d 1]], belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>.
+The major allergen in cats, '''Fel d 1''', belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>.
 It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking <ref name="[1]"/><ref name="[3]">WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref>.