Sandbox Reserved 1658: Difference between revisions
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<p align="justify">Neuropilin is a type I <ref name"structur function">Fumio Nakamura and Yoshio Goshima Bookshelf ID: NBK6408 https://www.ncbi.nlm.nih.gov/books/NBK6408/</ref> [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein] which has been highly conserved through evolution (see image on the right, determined by [https://consurfdb.tau.ac.il/ ConSurfDB]).[[Image:Structure evolution data.png | thumb]][[Image:Color scale2QQM evolution.png | thumb]] | <p align="justify">Neuropilin is a type I <ref name"structur function">Fumio Nakamura and Yoshio Goshima Bookshelf ID: NBK6408 https://www.ncbi.nlm.nih.gov/books/NBK6408/</ref> [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane protein] which has been highly conserved through evolution (see image on the right, determined by [https://consurfdb.tau.ac.il/ ConSurfDB]).[[Image:Structure evolution data.png | thumb]][[Image:Color scale2QQM evolution.png | thumb]] | ||
Two different types of Neuropilin have been discovered in vertebrates: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They have 44% of similarity<ref name="structural study">PMID: 17989695</ref> by comparing their [https://en.wikipedia.org/wiki/Amino_acid amino acid] sequences. In the human genome, it is located on the [https://en.wikipedia.org/wiki/Chromosome_10 Chromosome 10] and their molar weights fluctuate between 120 and 130 kDa<ref name="structural study"/>. | Two different types of Neuropilin have been discovered in vertebrates: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They have 44% of similarity<ref name="structural study">PMID: 17989695</ref> by comparing their [https://en.wikipedia.org/wiki/Amino_acid amino acid] sequences. In the human genome, it is located on the [https://en.wikipedia.org/wiki/Chromosome_10 Chromosome 10] and their molar weights fluctuate between 120 and 130 kDa<ref name="structural study"/>. | ||
These proteins are particularly found in the membrane of the endothelial cells but the Neuropilin-1 is involved in several process such as [https://en.wikipedia.org/wiki/Axon axon] guidance during the embryonic development, recognition of the Vascular Endothelial cell Growth Factor ([[VEGF]]) and recognition of covid-19<ref name="COVID19">DOI: 10.1126/science.abd2985 </ref>.</p> | These proteins are particularly found in the membrane of the endothelial cells but the Neuropilin-1 is involved in several process such as [https://en.wikipedia.org/wiki/Axon axon] guidance during the [https://en.wikipedia.org/wiki/Human_embryonic_development embryonic development], recognition of the Vascular Endothelial cell Growth Factor ([[VEGF]]) and recognition of covid-19<ref name="COVID19">DOI: 10.1126/science.abd2985 </ref>.</p> | ||
== Structural highlights == | == Structural highlights == | ||
