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The ''Notch'' signalling pathway regulates cell-to-cell interaction, [https://en.wikipedia.org/wiki/Embryonic_development embryogenesis] as well as various other biological functions in adult tissues. It is a highly conserved pathway. Its relevance and clinical significance lies in the mutations of the ''Notch'' gene that have been identified as a contributing factor to an extensive range of cancers in mammals. These mutations can change the activity of the pathway, which can be a triggering factor in various types of diseases <ref >PMID: 22306179</ref> depending on the sub-type of the targeted ''Notch'' receptor and more importantly, causing it to play an oncogenic or tumor-suppressive role.<ref name="roles" /> | The ''Notch'' signalling pathway regulates cell-to-cell interaction, [https://en.wikipedia.org/wiki/Embryonic_development embryogenesis] as well as various other biological functions in adult tissues. It is a highly conserved pathway. Its relevance and clinical significance lies in the mutations of the ''Notch'' gene that have been identified as a contributing factor to an extensive range of cancers in mammals. These mutations can change the activity of the pathway, which can be a triggering factor in various types of diseases <ref >PMID: 22306179</ref> depending on the sub-type of the targeted ''Notch'' receptor and more importantly, causing it to play an oncogenic or tumor-suppressive role.<ref name="roles" /> | ||
The ''Notch'' signalling pathway has been studied | The ''Notch'' signalling pathway has been studied thoroughly and various aspects of this pathway are very well known. Despite this, it is essential to study the pathway further, so as to understand the role it plays in cancer development and explore new treatment strategies focusing on the ''Notch'' pathway. | ||
