Sandbox Reserved 1658: Difference between revisions

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== Disease ==

<p align="justify">Since neuropilins are involved in the development of the neuronal and cardiovascular system, abnormalities in these genes lead to abnormalities in cardiac, vascular and nervous development. A dysregulation of the activity of neuropilins is involved in many pathologies, such as cancers and cardiovascular diseases. Indeed, neuropilins stimulate many functions that increase tumor aggression such as immune tolerance or cell proliferation. For example, overexpression of NRP1 has been detected in many cancers, including leukemia, lymphoma and melanoma<ref name="maladie">DOI 10.1002/path.2989</ref>. It would stimulate migration, invasion and tumorigenesis. The role of NRP1 as a mediator of tumor development has been investigated and many observations show that overexpression of NRP1 is also involved in colon<ref name="colon">PMID: 15161648</ref> cancer, breast cancer, lung cancer and glioma.</p>

<p align="justify">Since neuropilins are involved in the development of the neuronal and cardiovascular system, abnormalities in these genes lead to abnormalities in cardiac, vascular and nervous development. A dysregulation of the activity of neuropilins is involved in many pathologies, such as cancers and [https://en.wikipedia.org/wiki/Cardiovascular_disease cardiovascular diseases]. Indeed, neuropilins stimulate many functions that increase tumor aggression such as [https://en.wikipedia.org/wiki/Immune_tolerance immune tolerance] or [https://en.wikipedia.org/wiki/Cell_proliferation cell proliferation]. For example, overexpression of NRP1 has been detected in many cancers, including [https://en.wikipedia.org/wiki/Leukemia leukemia], [https://en.wikipedia.org/wiki/Lymphoma lymphoma] and [https://en.wikipedia.org/wiki/Melanoma melanoma]<ref name="maladie">DOI 10.1002/path.2989</ref>. It would stimulate migration, invasion and tumorigenesis. The role of NRP1 as a mediator of tumor development has been investigated and many observations show that overexpression of NRP1 is also involved in colon<ref name="colon">PMID: 15161648</ref> cancer, breast cancer, lung cancer and glioma.</p>

== Role in covid contamination ==

Sandbox Reserved 1658: Difference between revisions

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@@ Line 43: / Line 43: @@
 == Disease ==
-<p align="justify">Since neuropilins are involved in the development of the neuronal and cardiovascular system, abnormalities in these genes lead to abnormalities in cardiac, vascular and nervous development. A dysregulation of the activity of neuropilins is involved in many pathologies, such as cancers and cardiovascular diseases. Indeed, neuropilins stimulate many functions that increase tumor aggression such as immune tolerance or cell proliferation. For example, overexpression of NRP1 has been detected in many cancers, including leukemia, lymphoma and melanoma<ref name="maladie">DOI 10.1002/path.2989</ref>. It would stimulate migration, invasion and tumorigenesis. The role of NRP1 as a mediator of tumor development has been investigated and many observations show that overexpression of NRP1 is also involved in colon<ref name="colon">PMID: 15161648</ref> cancer, breast cancer, lung cancer and glioma.</p>
+<p align="justify">Since neuropilins are involved in the development of the neuronal and cardiovascular system, abnormalities in these genes lead to abnormalities in cardiac, vascular and nervous development. A dysregulation of the activity of neuropilins is involved in many pathologies, such as cancers and [https://en.wikipedia.org/wiki/Cardiovascular_disease cardiovascular diseases]. Indeed, neuropilins stimulate many functions that increase tumor aggression such as [https://en.wikipedia.org/wiki/Immune_tolerance immune tolerance] or [https://en.wikipedia.org/wiki/Cell_proliferation cell proliferation]. For example, overexpression of NRP1 has been detected in many cancers, including [https://en.wikipedia.org/wiki/Leukemia leukemia], [https://en.wikipedia.org/wiki/Lymphoma lymphoma] and [https://en.wikipedia.org/wiki/Melanoma melanoma]<ref name="maladie">DOI 10.1002/path.2989</ref>. It would stimulate migration, invasion and tumorigenesis. The role of NRP1 as a mediator of tumor development has been investigated and many observations show that overexpression of NRP1 is also involved in colon<ref name="colon">PMID: 15161648</ref> cancer, breast cancer, lung cancer and glioma.</p>
 == Role in covid contamination ==