Sandbox Reserved 1660: Difference between revisions

Line 26:

The ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells are quite specific, because the recognition is based on a hydrophobic interaction between the ligand and the CD1d molecule. Thus, it limits the risk of other similar molecules to bind CD1d proteins and ensures that the immune response is accurate. Among these CD1d ligands, glycolipids from a marine sponge (alphagalactosylceramide or α-GalCer), bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules have been described<ref name="Immunity">Brutkiewicz, R. R. CD1d Ligands: The Good, the Bad, and the Ugly. The Journal of Immunology 2006, 177 (2), 769–775. https://doi.org/10.4049/jimmunol.177.2.769.</ref>.

The ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells are quite specific, because the recognition is based on a hydrophobic interaction between the ligand and the CD1d molecule. Thus, it limits the risk for other similar molecules to bind CD1d proteins and ensures that the immune response is accurate. Among these CD1d ligands, glycolipids from a marine sponge (alphagalactosylceramide or α-GalCer), bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules have been described<ref name="Immunity">Brutkiewicz, R. R. CD1d Ligands: The Good, the Bad, and the Ugly. The Journal of Immunology 2006, 177 (2), 769–775. https://doi.org/10.4049/jimmunol.177.2.769.</ref>.

</p>

<br>

Sandbox Reserved 1660: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 26: / Line 26: @@
 <p align="justify">
-The ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells are quite specific, because the recognition is based on a hydrophobic interaction between the ligand and the CD1d molecule. Thus, it limits the risk of other similar molecules to bind CD1d proteins and ensures that the immune response is accurate. Among these CD1d ligands, glycolipids from a marine sponge (alphagalactosylceramide or α-GalCer), bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules have been described<ref name="Immunity">Brutkiewicz, R. R. CD1d Ligands: The Good, the Bad, and the Ugly. The Journal of Immunology 2006, 177 (2), 769–775. https://doi.org/10.4049/jimmunol.177.2.769.</ref>.
+The ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells are quite specific, because the recognition is based on a hydrophobic interaction between the ligand and the CD1d molecule. Thus, it limits the risk for other similar molecules to bind CD1d proteins and ensures that the immune response is accurate. Among these CD1d ligands, glycolipids from a marine sponge (alphagalactosylceramide or α-GalCer), bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules have been described<ref name="Immunity">Brutkiewicz, R. R. CD1d Ligands: The Good, the Bad, and the Ugly. The Journal of Immunology 2006, 177 (2), 769–775. https://doi.org/10.4049/jimmunol.177.2.769.</ref>.
 </p>
 <br>