Sandbox Reserved 1644: Difference between revisions
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== Function == | == Function == | ||
<p align="justify">The mitochondrial Lon protease is an important regulator of mitochondrial [https://en.wikipedia.org/wiki/Metabolism metabolism] including the maintenance and repair of mitochondrial [https://en.wikipedia.org/wiki/DNA DNA] thanks to its proteolytic domain. This protein is also essential for homeostasis of mitochondria, and by regulating some regulatory proteins which have a short life or damaged proteins. LONP1 works as a gatekeeper for specific proteins imported into the mitochondrial matrix. It also contributes to the degradation of imported, aberrant, unprocessed proteins using its protease activity. | <p align="justify">The mitochondrial Lon protease is an important regulator of mitochondrial [https://en.wikipedia.org/wiki/Metabolism metabolism] including the maintenance and repair of mitochondrial [https://en.wikipedia.org/wiki/DNA DNA] thanks to its proteolytic domain. This protein is also essential for homeostasis of mitochondria, and by regulating some regulatory proteins which have a short life or damaged proteins. LONP1 works as a gatekeeper for specific proteins imported into the mitochondrial matrix. It also contributes to the degradation of imported, aberrant, unprocessed proteins using its protease activity.<ref>Matsushima, Y., Takahashi, K., Yue, S., Fujiyoshi, Y., Yoshioka, H., Aihara, M., ... & Kang, D. (2021). Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix. Communications biology, 4(1), 1-13.</ref> | ||
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