Sandbox Reserved 1644: Difference between revisions

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This protein has a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] and [https://en.wikipedia.org/wiki/Chaperone_(protein) '''chaperone''']-like activity, it cannot unfold aggregated proteins, but can participate in the assembling of some complexes). These two enzymatic activities are separated on two polypeptide chains forming a complex or two separate domains on the same polypeptide chain.

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The Lon protein has three main distinct domains: the first, the '''N-terminal''' domain, is specialised in '''substrate binding''' and [https://en.wikipedia.org/wiki/Oligomer '''oligomerization''']. The second, called the '''AAA+ domain''' (or A domain) corresponds to the fixation and hydrolysis site of the [https://biologydictionary.net/atp/ATP ATP]. Finally, the third domain located at the '''C-terminal''' is an active serine site leading to '''substrate degradation'''. This is a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] domain, called domain P <ref>He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, et Jing-Ren Zhang. « Multiple domains of bacterial and human Lon proteases define substrate selectivity ». Emerging Microbes & Infections 7 (17 août 2018). https://doi.org/10.1038/s41426-018-0148-4.

The Lon protein has three main distinct domains: the first, the '''N-terminal''' domain, is specialised in '''substrate binding''' and [https://en.wikipedia.org/wiki/Oligomer '''oligomerization''']. The second, called the '''AAA+ domain''' (or A domain) corresponds to the fixation and hydrolysis site of the [https://biologydictionary.net/atp/ATP ATP], it also has unfolding activity. Finally, the third domain located at the '''C-terminal''' is an active serine site leading to '''substrate degradation'''. This is a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] domain, called domain P <ref>He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, et Jing-Ren Zhang. « Multiple domains of bacterial and human Lon proteases define substrate selectivity ». Emerging Microbes & Infections 7 (17 août 2018). https://doi.org/10.1038/s41426-018-0148-4.

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Sandbox Reserved 1644: Difference between revisions

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 This protein has a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] and [https://en.wikipedia.org/wiki/Chaperone_(protein) '''chaperone''']-like activity, it cannot unfold aggregated proteins, but can participate in the assembling of some complexes). These two enzymatic activities are separated on two polypeptide chains forming a complex or two separate domains on the same polypeptide chain.
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-The Lon protein has three main distinct domains: the first, the '''N-terminal''' domain, is specialised in '''substrate binding''' and [https://en.wikipedia.org/wiki/Oligomer '''oligomerization''']. The second, called the '''AAA+ domain''' (or A domain) corresponds to the fixation and hydrolysis site of the [https://biologydictionary.net/atp/ATP ATP]. Finally, the third domain located at the '''C-terminal''' is an active serine site leading to '''substrate degradation'''. This is a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] domain, called domain P <ref>He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, et Jing-Ren Zhang. « Multiple domains of bacterial and human Lon proteases define substrate selectivity ». Emerging Microbes & Infections 7 (17 août 2018). https://doi.org/10.1038/s41426-018-0148-4.
+The Lon protein has three main distinct domains: the first, the '''N-terminal''' domain, is specialised in '''substrate binding''' and [https://en.wikipedia.org/wiki/Oligomer '''oligomerization''']. The second, called the '''AAA+ domain''' (or A domain) corresponds to the fixation and hydrolysis site of the [https://biologydictionary.net/atp/ATP ATP], it also has unfolding activity. Finally, the third domain located at the '''C-terminal''' is an active serine site leading to '''substrate degradation'''. This is a [https://en.wikipedia.org/wiki/Proteolysis '''proteolytic'''] domain, called domain P <ref>He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, et Jing-Ren Zhang. « Multiple domains of bacterial and human Lon proteases define substrate selectivity ». Emerging Microbes & Infections 7 (17 août 2018). https://doi.org/10.1038/s41426-018-0148-4.
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