1g6d: Difference between revisions

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[[Image:1g6d.gif|left|200px]]
{{Seed}}
[[Image:1g6d.png|left|200px]]


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{{STRUCTURE_1g6d|  PDB=1g6d  |  SCENE=  }}  
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'''STRUCTURE OF PEPTIDYL-D(CGCAATTGCG) IN THE PRESENCE OF ZINC IONS'''
===STRUCTURE OF PEPTIDYL-D(CGCAATTGCG) IN THE PRESENCE OF ZINC IONS===




==Overview==
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We have synthesized and crystallized in the presence of Zn(2+) ions the peptidyl-oligonucleotide adduct CH(3)CO-(Arg)(4)-NH-(CH(2))(6)-NH-p-d(CGCAATTGCG). This is the first structure obtained from a deoxyoligonucleotide crystallized in the presence of zinc ions. Zn ions are clearly visible in the 2.9 A resolution map. On the other hand, the peptide tail is not visible in the crystal structure as determined by X-ray diffraction. The terminal bases C1 and G10 are found in extra-helical positions. Their phosphates are ligands of a Zn(2+) ion, located in a special position of the unit cell. This ion plays an important role in the packing arrangement, since it binds four different DNA molecules. Two other Zn(2+) ions are also important for DNA packing. They interact specifically with the N7 atoms of the terminal G2 and G10 bases, but not with the internal G8. This result supports the hypothesis that transition metals do not interact with the bases of duplex DNA in the B form.
The line below this paragraph, {{ABSTRACT_PUBMED_11941511}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11941511 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11941511}}


==About this Structure==
==About this Structure==
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[[Category: X-ray structure]]
[[Category: X-ray structure]]
[[Category: Zn ion]]
[[Category: Zn ion]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:11:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:42:21 2008''

Revision as of 01:42, 1 July 2008

File:1g6d.png

Template:STRUCTURE 1g6d

STRUCTURE OF PEPTIDYL-D(CGCAATTGCG) IN THE PRESENCE OF ZINC IONS

Template:ABSTRACT PUBMED 11941511

About this Structure

Full crystallographic information is available from OCA.

Reference

Interaction of zinc ions with d(CGCAATTGCG) in a 2.9 A resolution X-ray structure., Soler-Lopez M, Malinina L, Tereshko V, Zarytova V, Subirana JA, J Biol Inorg Chem. 2002 Apr;7(4-5):533-8. Epub 2002 Feb 7. PMID:11941511

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