Sandbox Reserved 1648: Difference between revisions
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== '''Activation''' == | == '''Activation''' == | ||
The activation of the leptin receptor | The activation of the leptin receptor is done through the '''CRH2, IGD and FN III''' domains <ref> The Leptin Receptor Complex: Heavier Than Expected? : https://www.frontiersin.org/articles/10.3389/fendo.2017.00030/full </ref>. | ||
The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, <scene name='86/868181/Leu_13/1'>Leu13</scene> and Leu86 of leptin interact with '''<scene name='86/868181/Leu_504/1'>Leu504</scene>''' (pink in viewer) in CRH2 forming a bond via hydrophobic interactions<ref>Mapping of the interface between leptin and the leptin receptor CRH2 domain : https://jcs.biologists.org/content/118/11/2519 </ref>. In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, <scene name='86/868181/Leu_13/1'>Leu13</scene> and Leu86 of leptin interact with '''<scene name='86/868181/Leu_504/1'>Leu504</scene>''' (pink in viewer) in CRH2 forming a bond via hydrophobic interactions<ref>Mapping of the interface between leptin and the leptin receptor CRH2 domain : https://jcs.biologists.org/content/118/11/2519 </ref>. In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | ||
