Sandbox Reserved 1649: Difference between revisions

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	'''• Inhibition by CK2 indirectly on NR2A'''		'''• Inhibition by CK2 indirectly on NR2A'''

	[https://en.wikipedia.org/wiki/Casein_kinase_2 Casein Kinase 2] (CK2) determines the NR2 subunit content of synaptic NMDA. Indeed, CK2 phosphorylates NR2B subunit in response to activity, what regulates the number of synaptic NR2A and NR2B. Indeed, CK2 phosphorylation leads to NR2B endocytosis and remove NR2B from synapses, resulting in an increase in synaptic NR2A expression. <ref name="Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors">DOI 110.1016/j.neuron.2010.08.011</ref>		[https://en.wikipedia.org/wiki/Casein_kinase_2 Casein Kinase 2] (CK2) determines the NR2 subunit content of synaptic NMDA. Indeed, CK2 phosphorylates NR2B subunit in response to activity, what regulates the number of synaptic NR2A and NR2B. Indeed, CK2 [https://en.wikipedia.org/wiki/Phosphorylation phosphorylation] leads to NR2B endocytosis and remove NR2B from synapses, resulting in an increase in synaptic NR2A expression. <ref name="Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors">DOI 110.1016/j.neuron.2010.08.011</ref>

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