Sandbox Reserved 1649: Difference between revisions
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== Disease == | == Disease == | ||
Anti-nuclear antibodies produced in [https://en.wikipedia.org/wiki/Lupus systemic or systemic lupus erythematosus (SLE, SLE)] interact with the NR2A subunit of the NMDA receptor. This is because the Asp / Glu-Trp-Asp / Glu-Tyr-Ser / Gly pentapeptide is a molecular mimic of double-stranded DNA, so antibodies produced in a patient with SLE recognize this pentapeptide. The latter is also present in the structure of NR2A. Thus, these antibodies cross-interact with NR2A and therefore the NMDA receptor. This interaction can signal neuronal death by an [https://en.wikipedia.org/wiki/Excitotoxicity excitotoxic] mechanism. | Anti-nuclear antibodies produced in [https://en.wikipedia.org/wiki/Lupus systemic or systemic lupus erythematosus (SLE, SLE)] interact with the '''NR2A subunit of the NMDA receptor'''. This is because the Asp / Glu-Trp-Asp / Glu-Tyr-Ser / Gly pentapeptide is a molecular mimic of double-stranded DNA, so antibodies produced in a patient with SLE recognize this pentapeptide. The latter is also present in the structure of NR2A. Thus, these antibodies cross-interact with NR2A and therefore the NMDA receptor. This interaction can signal neuronal death by an [https://en.wikipedia.org/wiki/Excitotoxicity excitotoxic] mechanism. | ||
More generally, NMDA receptor dysfunction is implicated in multiple brain disorders, such as [https://en.wikipedia.org/wiki/Stroke stroke], [https://en.wikipedia.org/wiki/Chronic_pain chronic pain], and [https://en.wikipedia.org/wiki/Schizophrenia schizophrenia]. <ref name="antibody">DOI 10.1038/nm1101-1189 | More generally, NMDA receptor dysfunction is implicated in multiple brain disorders, such as [https://en.wikipedia.org/wiki/Stroke stroke], [https://en.wikipedia.org/wiki/Chronic_pain chronic pain], and [https://en.wikipedia.org/wiki/Schizophrenia schizophrenia]. <ref name="antibody">DOI 10.1038/nm1101-1189 | ||
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