1g7r: Difference between revisions

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[[Image:1g7r.jpg|left|200px]]
{{Seed}}
[[Image:1g7r.png|left|200px]]


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{{STRUCTURE_1g7r|  PDB=1g7r  |  SCENE=  }}  
{{STRUCTURE_1g7r|  PDB=1g7r  |  SCENE=  }}  


'''X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B'''
===X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B===




==Overview==
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X-ray structures of the universal translation initiation factor IF2/eIF5B have been determined in three states: free enzyme, inactive IF2/eIF5B.GDP, and active IF2/eIF5B.GTP. The "chalice-shaped" enzyme is a GTPase that facilitates ribosomal subunit joining and Met-tRNA(i) binding to ribosomes in all three kingdoms of life. The conserved core of IF2/eIF5B consists of an N-terminal G domain (I) plus an EF-Tu-type beta barrel (II), followed by a novel alpha/beta/alpha-sandwich (III) connected via an alpha helix to a second EF-Tu-type beta barrel (IV). Structural comparisons reveal a molecular lever, which amplifies a modest conformational change in the Switch 2 region of the G domain induced by Mg(2+)/GTP binding over a distance of 90 A from the G domain active center to domain IV. Mechanisms of GTPase function and ribosome binding are discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_11114334}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11114334 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11114334}}


==About this Structure==
==About this Structure==
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[[Category: Roll-Mecak, A.]]
[[Category: Roll-Mecak, A.]]
[[Category: Translational gtpase]]
[[Category: Translational gtpase]]
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