3bzq: Difference between revisions

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<StructureSection load='3bzq' size='340' side='right'caption='[[3bzq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='3bzq' size='340' side='right'caption='[[3bzq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3bzq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BZQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3bzq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BZQ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gnk|1gnk]], [[2pii|2pii]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glnB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bzq OCA], [https://pdbe.org/3bzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bzq RCSB], [https://www.ebi.ac.uk/pdbsum/3bzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bzq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bzq OCA], [https://pdbe.org/3bzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bzq RCSB], [https://www.ebi.ac.uk/pdbsum/3bzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bzq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GLNB_MYCTU GLNB_MYCTU]] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).  
[https://www.uniprot.org/uniprot/GLNB_MYCTU GLNB_MYCTU] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Owen, J L]]
[[Category: Owen JL]]
[[Category: Palaninathan, S K]]
[[Category: Palaninathan SK]]
[[Category: Reddy, M C]]
[[Category: Reddy MC]]
[[Category: Sacchettini, J C]]
[[Category: Sacchettini JC]]
[[Category: Shetty, N D]]
[[Category: Shetty ND]]
[[Category: Structural genomic]]
[[Category: Glnb]]
[[Category: Glnk]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Nitrogen regulatory]]
[[Category: Nucleotide-binding]]
[[Category: P-ii]]
[[Category: PSI, Protein structure initiative]]
[[Category: Signal transduction]]
[[Category: Signal transductory protein]]
[[Category: Signaling protein-transcription complex]]
[[Category: Tbsgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
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