1g88: Difference between revisions

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[[Image:1g88.~~gif~~|left|200px]]

[[Image:1g88.png|left|200px]]

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~~'''~~S4AFL3ARG515 MUTANT~~'''~~

===S4AFL3ARG515 MUTANT===

~~==Overview==~~

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~~Smad proteins mediate~~ the ~~transforming growth factor beta responses. C-terminal phosphorylation of R-Smads leads~~ to the ~~recruitment of Smad4 and the formation of active signaling complexes~~. ~~We investigated the mechanism of phosphorylation-induced Smad complex formation with an activating pseudo-phosphorylated Smad3~~. ~~Pseudo-phosphorylated Smad3 has a greater propensity to homotrimerize~~, ~~and recruits Smad4 to form a heterotrimer containing two Smad3 and one Smad4. The trimeric interaction~~ is ~~mediated through conserved interfaces to which tumorigenic mutations map~~. ~~Furthermore, a conserved Arg residue within the L3 loop, located near the C~~-~~terminal phosphorylation sites of the neighboring subunit, is essential for trimerization. We propose that the phosphorylated C~~-~~terminal residues interact with the L3 loop of the neighboring subunit to stabilize the trimer interaction.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11224571}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11224571 is the PubMed ID number.

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==About this Structure==

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[[Category: L3 loop mutant]]

[[Category: Transcriptional factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:16:01 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:52:14 2008''

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-[[Image:1g88.gif|left|200px]]
+{{Seed}}
+[[Image:1g88.png|left|200px]]
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 {{STRUCTURE_1g88|  PDB=1g88  |  SCENE=  }}
-'''S4AFL3ARG515 MUTANT'''
+===S4AFL3ARG515 MUTANT===
-==Overview==
+<!--
-Smad proteins mediate the transforming growth factor beta responses. C-terminal phosphorylation of R-Smads leads to the recruitment of Smad4 and the formation of active signaling complexes. We investigated the mechanism of phosphorylation-induced Smad complex formation with an activating pseudo-phosphorylated Smad3. Pseudo-phosphorylated Smad3 has a greater propensity to homotrimerize, and recruits Smad4 to form a heterotrimer containing two Smad3 and one Smad4. The trimeric interaction is mediated through conserved interfaces to which tumorigenic mutations map. Furthermore, a conserved Arg residue within the L3 loop, located near the C-terminal phosphorylation sites of the neighboring subunit, is essential for trimerization. We propose that the phosphorylated C-terminal residues interact with the L3 loop of the neighboring subunit to stabilize the trimer interaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_11224571}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11224571 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11224571}}
 ==About this Structure==
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 [[Category: L3 loop mutant]]
 [[Category: Transcriptional factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:16:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:52:14 2008''