7t3n: Difference between revisions

Latest revision as of 10:01, 14 December 2022

R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2)

Structural highlights

7t3n is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	C5B, I7Y, P1L
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VGLU2_RAT Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Fremeau RT Jr, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, Bellocchio EE, Fortin D, Storm-Mathisen J, Edwards RH. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. 2001 Aug 2;31(2):247-60. PMID:11502256
↑ Hayashi M, Otsuka M, Morimoto R, Hirota S, Yatsushiro S, Takeda J, Yamamoto A, Moriyama Y. Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. J Biol Chem. 2001 Nov 16;276(46):43400-6. Epub 2001 Sep 10. PMID:11551935 doi:https://dx.doi.org/10.1074/jbc.M106244200
↑ Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci. 2001 Nov 15;21(22):RC181. PMID:11698619
↑ Takamori S, Rhee JS, Rosenmund C, Jahn R. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J Neurosci. 2001 Nov 15;21(22):RC182. PMID:11698620
↑ Juge N, Yoshida Y, Yatsushiro S, Omote H, Moriyama Y. Vesicular glutamate transporter contains two independent transport machineries. J Biol Chem. 2006 Dec 22;281(51):39499-506. Epub 2006 Oct 17. PMID:17046815 doi:https://dx.doi.org/M607670200
↑ Mackenzie B, Illing AC, Morris ME, Varoqui H, Erickson JD. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Neurochem Res. 2008 Feb;33(2):238-47. Epub 2007 Dec 13. PMID:18080752 doi:https://dx.doi.org/10.1007/s11064-007-9546-z

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OCA

[1] Fremeau RT Jr, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, Bellocchio EE, Fortin D, Storm-Mathisen J, Edwards RH. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. 2001 Aug 2;31(2):247-60. PMID:11502256

[2] Hayashi M, Otsuka M, Morimoto R, Hirota S, Yatsushiro S, Takeda J, Yamamoto A, Moriyama Y. Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. J Biol Chem. 2001 Nov 16;276(46):43400-6. Epub 2001 Sep 10. PMID:11551935 doi:https://dx.doi.org/10.1074/jbc.M106244200

[3] Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci. 2001 Nov 15;21(22):RC181. PMID:11698619

[4] Takamori S, Rhee JS, Rosenmund C, Jahn R. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J Neurosci. 2001 Nov 15;21(22):RC182. PMID:11698620

[5] Juge N, Yoshida Y, Yatsushiro S, Omote H, Moriyama Y. Vesicular glutamate transporter contains two independent transport machineries. J Biol Chem. 2006 Dec 22;281(51):39499-506. Epub 2006 Oct 17. PMID:17046815 doi:https://dx.doi.org/M607670200

[6] Mackenzie B, Illing AC, Morris ME, Varoqui H, Erickson JD. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Neurochem Res. 2008 Feb;33(2):238-47. Epub 2007 Dec 13. PMID:18080752 doi:https://dx.doi.org/10.1007/s11064-007-9546-z

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7t3n is ON HOLD  until Paper Publication
+==R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2)==
+<StructureSection load='7t3n' size='340' side='right'caption='[[7t3n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Li, F., Stroud, R.M., Edwards, R.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7t3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T3N FirstGlance]. <br>
-Description: R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5B:(1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC+ACID'>C5B</scene>, <scene name='pdbligand=I7Y:(2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl+4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside'>I7Y</scene>, <scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t3n OCA], [https://pdbe.org/7t3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t3n RCSB], [https://www.ebi.ac.uk/pdbsum/7t3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t3n ProSAT]</span></td></tr>
-[[Category: Stroud, R.M]]
+</table>
-[[Category: Edwards, R.H]]
+== Function ==
-[[Category: Li, F]]
+[https://www.uniprot.org/uniprot/VGLU2_RAT VGLU2_RAT] Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.<ref>PMID:11502256</ref> <ref>PMID:11551935</ref> <ref>PMID:11698619</ref> <ref>PMID:11698620</ref> <ref>PMID:17046815</ref> <ref>PMID:18080752</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Edwards RH]]
+[[Category: Li F]]
+[[Category: Stroud RM]]

7t3n: Difference between revisions

Latest revision as of 10:01, 14 December 2022

R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2)

Structural highlights

Function

References

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