Protein G

spinqualitylabelsall models Protein G domain II (grey) complex with mouse Fab heavy chain (red) and light chain (aqua) (PDB code 1uwx). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Protein G or immunoglobulin-binding protein G (ProG) is a cell surface protein from Streptococcal bacteria which binds Fab and Fc regions of immunoglobulins. For ProG immunoglobulin-binding domain see Chameleon peptide.

3D Structures of protein G

Updated on 03-August-2026 {{#tree:id=OrganizedByTopic|openlevels=0|

• Streptococcus Protein G domain I or GBI residues 2-68

• • Chameleon peptide – StProG domain B1 – Streptococcus - NMR
    
  • 8ug0, 8ug2 – StProG domain B1 (mutant)
    
  • 6hka – StProG domain B1/ATM peptide
    
  • 6hpj – StProG domain B1/ASF-1 + RNA - NMR
    
  • 6u8c – StProG + antibody
    

• Streptococcus Protein G residues 56-118

• • 1uwx – StProG + Igg1 Fab
    
  • 1qkz – StProG (mutant) + Igg1 Fab + peptide antigen
    

• Streptococcus Protein G residues 189-244

• • 1em7 – StProG (mutant)
    

• Streptococcus Protein G residues 228-282

• • 1mpe, 1pga, 1pgb, 1q10, 2ju6, 2rmm, 2rpv, 2j52, 2j53, 2k0p - StProG
    
  • 1mvk – StProG (mutant)
    
  • 7qtr, 7qts - StProG - NMR
    
  • 1mvk – StProG (mutant) - NMR
    
  • 5jxv – StProG/ubiquitin-like protein - NMR
    
  • 2den – StProG/ubiquitin-like protein + ubiquitin - NMR
    
  • 9cht – StProG/p53 + E3A + protein E6 – Cryo EM
    

• Streptococcus Protein G residues 254-299

• • 1gjs, 1gjt - StProG albumin-binding domain - NMR
    

• Streptococcus Protein G residues 300-357

• • 1igd, 1pgx, 2igd, 3fil - StProG
    
  • 3v3x, 6c9o, 6nl6, 6nl7, 6nl8, 6nl9, 6nlb, 7da8, 9i2i, 9t8z, 12lo – StProG (mutant)
    
  • 2plp, 8um7, 8um9, 8uma, 8umb, 8ums - StProG - NMR
    
  • 1fcl, 1fd6, 2jsv, 2kq4, 2kwd - StProG (mutant) - NMR
    
  • 1igc – StProG domain III + Igg1 Fab
    
  • 9rxk – StProG + Pit2
    
  • 3ui3 – StProG/VAPD
    
  • 2kn4 – StProG domain B1/splicing factor - NMR
    
  • 9g4t – StProG/CSOSCA – Cryo EM
    
  • 6v9i – StProG/cullin-5 + RBX2 – Cryo EM
    
  • [[2khu], 2mbb – StProG/DNA polymerase iota
    
  • 2khw – StProG/DNA polymerase iota + ubiquitin
    
  • 5lde – StProG/VFLIP
    

• Streptococcus Protein G residues 328-384

• • 9kl7, 9kls, 9klt, 9klu - StProG (mutant)
    

• Streptococcus Protein G residues 367-430

• • 2on8 - StProG
    
  • 2onq – StProG (mutant)
    
  • 1gb4, 6njf – StProG (mutant) – NMR
    
  • 1fcc – StProG + Igg1 Fc
    

• Streptococcus Protein G domain III or GB3 residues 443-497

• • 8wcj - StProG (mutant)
    
  • 1p7e, 1p7f, 2lum - StProG - NMR
    
  • 1zxh - StProG (mutant) - NMR
    
  • 8tfr - StProG + antibody
    
  • 6uyg - StProG + envelope glycoprotein + antibody
    
  • 6w00 - StProG + peptide + antibody
    

• Protein G

• • 1gb1, 2gb1, 2igg, 2igh - SgProG immunoglobulin-binding domain – Streptomyces griseus – NMR
    
  • 2igg, 2igh - SgProG immunoglobulin-binding domains II+III – NMR
    
  • 2gi9, 2qmt – SaProG domain B1 (mutant) – Staphylococcus aureus
    
  • 2klk - SaProG immunoglobulin-binding domain - NMR
    
  • 9fa8 - EcProG antibody-binding domain C2 1-65 – Escherichia coli - NMR
    
  • 9a9t, 9a9u - EcProG antibody-binding domain C2 1-65 (mutant) – NMR
    
  • 8r40 - ProG immunoglobulin-binding domain III 201-281+ diabody – Rabies virus
    

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel