COVID-19 AlphaFold2 Models

spinqualitylabelsall models SARS-CoV-2 Protein N Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. Model Confidence:   Very high (pLDDT > 90)   Confident (90 > pLDDT > 70)   Low (70 > pLDDT > 50)   Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation. As an example, to the right, is an AlphaFold2 3D model of the SARS CoV-2 Protein N (UniProt ID: QHD43423) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 5. At present, there a still a number of proteins from the SARS CoV-2 virus whose 3D structures have not yet been experimentally determined. AlphaFold2 was used to predict these structures using the MIT ColabFold server. For each prediction, five 3D models were predicted, ranked from 1 to 5 (with 1 being the best). Views of these AlphaFold2 predictions can be seen on the Proteopedia pages: SARS-CoV-2 protein M - Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. SARS-CoV-2 protein N - The primary function of the Nucleocapsid protein (N-protein) is to package the viral genome into a helical ribonucleoprotein (RNP) complex. SARS-CoV-2 protein ORF10 - It is currently unclear whether this region translates into a functional protein.]

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman