1gam: Difference between revisions

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[[Image:1gam.jpg|left|200px]]
{{Seed}}
[[Image:1gam.png|left|200px]]


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{{STRUCTURE_1gam|  PDB=1gam  |  SCENE=  }}  
{{STRUCTURE_1gam|  PDB=1gam  |  SCENE=  }}  


'''GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN'''
===GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN===




==Overview==
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We use protein engineering and crystallography to simulate aspects of the early evolution of beta gamma-crystallins by observing how a single domain oligomerizes in response to changes in a sequence extension. The crystal structure of the C-terminal domain of gamma beta-crystallin with its four-residue C-terminal extension shows that the domain does not form a symmetric homodimer analogous to the two-domain pairing in beta gamma-crystallins. Instead the C-terminal extension now forms heterologous interactions with other domains leading to the solvent exposure of the natural hydrophobic interface with a consequent loss in protein solubility. However, this domain truncated by just the C-terminal tyrosine forms a symmetric homodimer of domains in the crystal lattice.
The line below this paragraph, {{ABSTRACT_PUBMED_8605629}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8605629}}


==About this Structure==
==About this Structure==
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[[Category: Gamma crystallin b]]
[[Category: Gamma crystallin b]]
[[Category: Multigene family]]
[[Category: Multigene family]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:21:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:00:02 2008''

Revision as of 02:00, 1 July 2008

File:1gam.png

Template:STRUCTURE 1gam

GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 8605629

About this Structure

1GAM is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins., Norledge BV, Mayr EM, Glockshuber R, Bateman OA, Slingsby C, Jaenicke R, Driessen HP, Nat Struct Biol. 1996 Mar;3(3):267-74. PMID:8605629

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