Biological Unit: Difference between revisions
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The most reliable way to find out the biological unit is to read the literature and/or contact experts on the molecule in question. Short of such efforts, here are some suggestions: | The most reliable way to find out the biological unit is to read the literature and/or contact experts on the molecule in question. Short of such efforts, here are some suggestions: | ||
*When the "author determined" biological unit stated in REMARK 350 has a ''different number of [[chains]]'' than the [[asymmetric unit]], the biological unit is more likely to be correct, simply because the difference in chains shows that the authors gave REMARK 350 some real consideration. | *When the "author determined" biological unit stated in REMARK 350 has a ''different number of [[chains]]'' than the [[asymmetric unit]], the biological unit is more likely to be correct, simply because the difference in chains shows that the authors gave REMARK 350 some real consideration. | ||
*When the "author determined biological unit stated in REMARK 350 has the ''same number of chains, but in a different conformation'', than the asymmetric unit, the stated biological unit is more likely to be correct, for the same reason given in the previous case above. An example is [[1qrd]], given in the table in the ''Examples'' section above. | *When the "author determined" biological unit stated in REMARK 350 has the ''same number of chains, but in a different conformation'', than the asymmetric unit, the stated biological unit is more likely to be correct, for the same reason given in the previous case above. An example is [[1qrd]], given in the table in the ''Examples'' section above. | ||
*When the "author determined" biological unit stated in REMARK 350 has the ''same number of chains, in the same conformation'', as the asymmetric unit, the stated biological unit is less likely to be correct. There is a significant chance that the authors failed to state a known biological unit in REMARK 350 (see examples above). | *When the "author determined" biological unit stated in REMARK 350 has the ''same number of chains, in the same conformation'', as the asymmetric unit, the stated biological unit is less likely to be correct. There is a significant chance that the authors failed to state a known biological unit in REMARK 350 (see examples above). | ||
*When a biological unit is determined ''only by software'', it is less likely to be correct. The software makes an educated guess based upon the characteristics of the contacts present in the protein crystal, but it is sometimes incorrect. | *When a biological unit is determined ''only by software'', it is less likely to be correct. The software makes an educated guess based upon the characteristics of the contacts present in the protein crystal, but it is sometimes incorrect. | ||
