Sandbox Reserved 1726: Difference between revisions

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{{Template:CH462_Biochemistry_II_2022}}

==~~Your Heading Here (maybe something like 'Structure')~~==

==Anaplastic Lymphoma Kinase==

This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Background ==

== Structure ==

=== Domains ===

==== Three Helix Bundle-like Domain ====

The three helix bundle-like domain mainly has a structural function overall as it interacts with the tumor necrosis factor-like domain upon ligand binding.

==== Poly-Glycine Domain ====

Located between the three helix bundle-like domain and the tumor necrosis factor-like domain, the poly-glycine domain has an important structural role.

==== Tumor Necrosis Factor-like Domain ====

The tumor necrosis factor-like domain interacts with the three helix bundle-like domain to begin the conformational changes associated with ligand binding. The three helix bundle-like domain's alpha helix interacts with the helix alpha-1' and beta strand A-1'. This domain also assists in mediating ligand binding with the epidermal growth factor-like domain.

==== Epidermal Growth Factor-like Domain ====

The epidermal growth factor-like domain is very malleable and repositioning of this domain is essential for activation of the protein. This domain is able to undergo conformational changes with the ligand bound and when in contact with the tumor necrosis factor-like domain.

== Function ==

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@@ Line 1: / Line 1: @@
 {{Template:CH462_Biochemistry_II_2022}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-==Your Heading Here (maybe something like 'Structure')==
+==Anaplastic Lymphoma Kinase==
 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
+== Background ==
+== Structure ==
+=== Domains ===
+==== Three Helix Bundle-like Domain ====
+The three helix bundle-like domain mainly has a structural function overall as it interacts with the tumor necrosis factor-like domain upon ligand binding.
+==== Poly-Glycine Domain ====
+Located between the three helix bundle-like domain and the tumor necrosis factor-like domain, the poly-glycine domain has an important structural role.
+==== Tumor Necrosis Factor-like Domain ====
+The tumor necrosis factor-like domain interacts with the three helix bundle-like domain to begin the conformational changes associated with ligand binding. The three helix bundle-like domain's alpha helix interacts with the helix alpha-1' and beta strand A-1'. This domain also assists in mediating ligand binding with the epidermal growth factor-like domain.
+==== Epidermal Growth Factor-like Domain ====
+The epidermal growth factor-like domain is very malleable and repositioning of this domain is essential for activation of the protein. This domain is able to undergo conformational changes with the ligand bound and when in contact with the tumor necrosis factor-like domain.
 == Function ==